Probe Array Technology for Life Science Applications
Jürgen Brugger EPFL
Nico De Rooij EPFL
Hans Peter Herzig EPFL
Agnese Mariotti UNIL
Ernst Meyer UniBasel
Pedro Romero UNIL
Horst Vogel EPFL
Project Description
Methods that allow the routine, early, non-invasive detection of cancer willallow early treatment with better survival rates. The development oflaboratory tools for the screening of cancer drugs on a cell level, allowing monitoring the cells’ adhesion and biomechanical responses, represent promising paths in the search of cancer therapies. The projects objectives include the optimization of nanomechanical sensing for early cancer detection, with a case study for head and neck cancer patients. Further, parallel force spectroscopy is being developed that allow the statistically relevant examination of the nanomechanical responses of numerous cells simultaneously.
Real-Time Viscosity and Mass Density Sensors Requiring Microliter Sample Volume Based on Nanomechanical Resonators BA Bircher, L Duempelmann, K Renggli, HP Lang, C Gerber, N Bruns, T Braun Analytical chemistry 85 (18), 8676-8683 (2013)
Development of Robust and Standardized Cantilever Sensors Based on Biotin/Neutravidin Coupling for Antibody Detection J Zhang, HP Lang, F Battiston, N Backmann, F Huber, C Gerber Sensors 13 (4), 5273-5285 (2013)
Direct detection of a BRAF mutation in total RNA from melanoma cells using cantilever arrays F Huber, HP Lang, N Backmann, D Rimoldi, C Gerber Nature nanotechnology 8 (2), 125-129 (2013)
Piezoresistive Membrane-Type Surface Stress Sensor Arranged In Arrays For Cancer Diagnosis Through Breath Analysis F. Loizeau, H.P. Lang, T. Akiyama, S. Gautsch, P. Vettiger, A. Tonin, G. Yoshikawa, Ch. Gerber, N. de Rooij Proc. 26th IEEE International Conference On Micro Electro Mechanical Systems MEMS 2013, p. 621-624 (2013)
